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Think about alternant therapies that aren't moderate CYP3A inducers all through remedy with mitapivat. If not able to keep away from coadministration, observe Hb and titrate further than fifty mg BID, if needed, but do not exceed mitapivat dose of 100 mg BID. .

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Barbiturates could cause fetal injury when administered to a pregnant female; retrospective, situation-managed scientific studies have advised a link between maternal intake of barbiturates and a higher-than-anticipated incidence of fetal abnormalities

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With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.

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